Talsupram hydrochloride

Cat. No. 4352

Talsupram hydrochloride C20H25NS.HCl [25487-28-9]

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Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-phenylbenzo[c]thiophene-1-propanamine hydrochloride

Biological Activity

Selective noradrenalin re-uptake inhibitor; exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Antidepressant.

Technical Data

M.Wt:
347.95
Formula:
C20H25NS.HCl
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
25487-28-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Schou et al (2006) Synthesis and positron emission tomography evaluation of three norepinephrine transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1.

McConathy et al (2004) Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter. Nucl.Med.Biol. 31 (6) 705. PMID: 15246361.

Rowlett et al (2004) Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors. J.Pharmacol.Exp.Ther. 310 342. PMID: 14985417.

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Keywords: Talsupram hydrochloride, supplier, norepinephrine, reuptake, inhibitors, inhibits, noradrenaline, noradrenalin, transporters, NET, antidepressants, selective, Tocris Bioscience, Adrenergic Transporter Inhibitor products

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