JHW 007 hydrochloride

Cat. No. 4351

JHW 007 hydrochloride C24H29F2NO.HCl [202645-74-7]

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Chemical Name: (3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane hydrochloride

Biological Activity

Dopamine uptake inhibitor; displays high affinity for the dopamine transporter (DAT) (Ki = 25 nM compared to 1330 and 1730 for NET and SERT respectively). Suppresses the effects of cocaine administration in a dose-dependent manner and decreases cocaine and methamphetamine self-administration in rats.

Technical Data

M.Wt:
421.95
Formula:
C24H29F2NO.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
202645-74-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hiranita et al (2014 ) Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats. J.Pharmacol.Exp.Ther. 348 174. PMID: 24194527.

Kristensen et al (2011) SLC6 neurotransmitter transporters: structure, function, and regulation. Pharm.Rev. 63 (3) 585.

Kopajtic et al (2010) Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability. J.Pharmacol.Exp.Ther. 335 703. PMID: 20855444.

Velaquez-Sanchez et al (2010) The high affinity dopamine uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization. Eur.Neuropsychopharmacol. 20 501. PMID: 20413276.

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Citations are publications that use Tocris products. Selected citations for JHW 007 hydrochloride include:

Andersen et al (2015) Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter. Stem Cell Reports 5 15650. PMID: 26503701.

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Keywords: JHW 007 hydrochloride, supplier, JHW007, dopamine, uptake, inhibitors, inhibits, DAT, transporter, Tocris Bioscience, Dopamine Transporter Inhibitor products

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