Cat. No. 4349

Olanzapine C17H20N4S [132539-06-1]

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Chemical Name: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

Biological Activity

Antagonist of 5-HT2A and dopamine D2 receptors (Ki values are 4 and 11 nM respectively). Also displays affinity for a range of other receptors including D1 and D4, 5-HT2C, α1, H1 and M1-4 receptors (Ki values range between 1.9 and 31 nM) . Atypical antipsychotic. Displays anticholinergic properties.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Tollefson and Taylor (2000) Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent. CNS Drug Reviews 6 303.

Bymaster et al (1996) Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology 14 87. PMID: 8822531.

Moore et al (1992) The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent. J.Pharmacol.Exp.Ther. 262 545. PMID: 1354253.

If you know of a relevant reference for Olanzapine please let us know.

Citations are publications that use Tocris products. Selected citations for Olanzapine include:

Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Nat Methods 40 766. PMID: 25249058.

Do you know of a great paper that uses Olanzapine from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Olanzapine, supplier, 5ht2a, 5ht2c, serotonergics, dopamine, dopaminergics, d2, antagonists, atypical, antipsychotics, thienobenzodiazepine, Tocris Bioscience, Non-selective 5-HT2 Antagonist products

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