UNC 0638

Cat. No. 4343

UNC 0638 C30H47N5O2 [1255517-77-1]

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Chemical Name: 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

Biological Activity

Selective inhibitor of G9a and GLP histone lysine methyltransferases (IC50 values are < 15 nM and 19 nM for G9a and GLP respectively, and > 10000 nM for a range of other histone methyltransferases). Potently inhibits dimethylation of H3K9 in MCF-7 cells (IC50 = 70 nM). Cell permeable.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 0638 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 0638 is reviewed on the chemical probes website.

Technical Data

M.Wt:
509.73
Formula:
C30H47N5O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol and to 100 mM in 1eq. HCl
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1255517-77-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Liu et al (2011) Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J.Med.Chem. 54 6139. PMID: 21780790.

Vedadi et al (2011) A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat.Chem.Biol. 7 566. PMID: 21743462.

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Keywords: UNC 0638, supplier, G9a, GLP, histone, lysine, methyltransferases, HMTs, HMTases, epigenetics, histone, modifications, H3K9, H3K9me2, potent, selective, inhibits, inhibitors, UNC0638, Tocris Bioscience, Lysine Methyltransferase Inhibitor products

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