A 582941

Cat. No. 4341

A 582941 C17H20N4 [848591-90-2]

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Chemical Name: Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole

Biological Activity

Selective α7 nAChR partial agonist; exhibits high affinity for both rat and human α7 receptors (Ki values are 10.8 and 16.7 nM respectively). Displays ~15-fold selectivity for α7 over 5-HT3 receptors (Ki = 150 nM for 5-HT3).

Technical Data

M.Wt:
280.37
Formula:
C17H20N4
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
848591-90-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Anderson et al (2008) [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity α7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain. J.Pharmacol.Exp.Ther. 324 179. PMID: 17959745.

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Keywords: A 582941, supplier, A582941, selective, alpha7, α7, a7, nicotinics, receptors, partial, agonists, Tocris Bioscience, Nicotinic (α7) Receptor Agonist products

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