TG 003

Cat. No. 4336

TG 003 C13H15NO2S [719277-26-6]

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Chemical Name: (1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone

Biological Activity

Potent, ATP-competitive inhibitor of Clk-family kinases (IC50 values are 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3). Also inhibits DYRK1A/B (IC50 values are 24 and 34 nM respectively). Suppresses serine/arginine-rich protein phosphorylation; affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo.

Technical Data

M.Wt:
249.33
Formula:
C13H15NO2S
Solubility:
Soluble to 100 mM in DMSO and to 75 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
719277-26-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Foucourt et al (2014) Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II. Molecules 19 15411. PMID: 25264830.

Muraki et al (2004) Manipulation of alternative splicing by a newly developed inhibitor of Clks. J.Biol.Chem. 279 24246. PMID: 15010457.

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Keywords: TG 003, supplier, TG003, ATP-competitive, Cdc2-like, inhibitors, inhibits, Clk, Clk-family, kinases, DYRK1A, DYRK1B, DYRK1A/B, Tocris Bioscience, Cdc2-like Kinase Inhibitor products

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