PSB 0777 ammonium salt

Cat. No. 4334

PSB 0777 ammonium salt C18H20N5O7S2.NH4

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Chemical Name: 4-[2-[(6-Amino-9-b-D-ribofuranosyl-9H-purin-2-yl)thio]ethyl]benzenesulfonic acid ammonium salt

Biological Activity

Potent adenosine A2A receptor full agonist (Ki = 44.4 nM for rat brain striatal A2A receptors). Exhibits subtype selectivity for A2A receptors over A1, A2B and A3 receptors (Ki ≥ 10 000 nM for rat A1, human A2B and human A3 receptors). Potentiates acetylcholine-induced contractions in ex vivo rat ileum/jejunum segments.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

El-Tayeb et al (2012) Development of polar adenosine A2A receptor agonists for inflammatory bowel disease: synergism with A2B antagonists. ACS Med.Chem.Lett. 2 890.

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Citations are publications that use Tocris products.

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Keywords: PSB 0777 ammonium salt, supplier, Adenosine, A2A, receptors, agonists, potent, subtypes, selective, PSB0777, ammonium, salt, Tocris Bioscience, Adenosine A2A Receptor Agonist products

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