PSB 1114

Cat. No. 4333

PSB 1114 C10H11F2N2Na4O13P3S [1657025-60-9]

Price and Availability

For PSB 1114 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-Thiouridine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt

Biological Activity

Potent, selective P2Y2 agonist (EC50 = 0.134 μM). Displays >60-fold selectivity versus P2Y4 and P2Y6 receptors.

Technical Data

M.Wt:
622.14
Formula:
C10H11F2N2Na4O13P3S
Solubility:
Soluble in water (supplied pre-dissolved at a concentration of 10mM)
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1657025-60-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

El-Tayeb et al (2011) Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J.Med.Chem. 54 2878. PMID: 21417463.

If you know of a relevant reference for PSB 1114 please let us know.

Citations are publications that use Tocris products. Selected citations for PSB 1114 include:

Roshanravan and Dryer (2014) ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species. Neuropsychopharmacology 306 F1088. PMID: 24553432.

Do you know of a great paper that uses PSB 1114 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: PSB 1114, supplier, PSB1114, P2Y2, receptors, agonist, purinergic, P2Y, 2, agonists, purinoceptors, Tocris Bioscience, Purinergic (P2Y) Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

P2 Receptors Scientific Review

Written by Kenneth Jacobson

P2X and P2Y Receptors Scientific Review

Our Purine Receptor review gives an overview of the subtypes and structures of the P2 receptor family, and the pharmacological ligands used to study them. Request copy or view PDF today.

divider line

Cardiovascular Life Science Poster

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy or view PDF today.

divider line

New Products in this Area

Prasugrel

Irreversible P2Y12 antagonist; antiplatelet and orally active

BigLEN (rat)

Potent GPR171 agonist

BigLEN (mouse)

GPR171 agonist

BPTU

P2Y1 allosteric antagonist

AC 265347

CaSR biased allosteric modulator

7α,25-Dihydroxycholesterol

Highly potent GPR183 (EBI2) agonist

AR-C 69931 tetrasodium salt

Highly potent P2Y12 antagonist

FTY 720

Potent S1P receptor agonist; also immunosuppressant

Cinacalcet hydrochloride

Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

AMG 837 hemicalcium salt

Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist

UMB 68

GHB receptor ligand

Sign-up for new product e-alerts
divider line

Bio-Techne Events

SENC 2017

17th National Congress of the Spanish Society of Neuroscience

September 27 - 30, 2017

Alicante, Spain