PSB 1114

Cat. No. 4333

PSB 1114 C10H11F2N2Na4O13P3S [1657025-60-9]

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Chemical Name: 4-Thiouridine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt

Biological Activity

Potent, selective P2Y2 agonist (EC50 = 0.134 μM). Displays >60-fold selectivity versus P2Y4 and P2Y6 receptors.

Technical Data

M.Wt:
622.14
Formula:
C10H11F2N2Na4O13P3S
Solubility:
Soluble in water (supplied pre-dissolved at a concentration of 10mM)
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1657025-60-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

El-Tayeb et al (2011) Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J.Med.Chem. 54 2878. PMID: 21417463.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for PSB 1114 include:

Roshanravan and Dryer (2014) ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species. Neuropsychopharmacology 306 F1088. PMID: 24553432.

Do you know of a great paper that uses PSB 1114 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: PSB 1114, supplier, PSB1114, P2Y2, receptors, agonist, purinergic, P2Y, 2, agonists, purinoceptors, Tocris Bioscience, Purinergic (P2Y) Receptor Agonist products

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