Cat. No. 4333
Chemical Name: 4-Thiouridine-5'-O-(β,γ-difluoromethyl
Biological ActivityPotent, selective P2Y2 agonist (EC50 = 0.134 μM). Displays >60-fold selectivity versus P2Y4 and P2Y6 receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
El-Tayeb et al (2011) Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J.Med.Chem. 54 2878. PMID: 21417463.
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Citations are publications that use Tocris products. Selected citations for PSB 1114 include:
Roshanravan and Dryer (2014) ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species. Neuropsychopharmacology 306 F1088. PMID: 24553432.
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Keywords: PSB 1114, supplier, PSB1114, P2Y2, receptors, agonist, purinergic, P2Y, 2, agonists, purinoceptors, Tocris Bioscience, Purinergic (P2Y) Receptor Agonist products
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