PhiKan 083

Cat. No. 4326

PhiKan 083 C16H18N2.HCl [880813-36-5]

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Chemical Name: 9-Ethyl-N-methyl-9H-carbazole-3-methanamine hydrochloride

Biological Activity

p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.

Technical Data

Soluble to 50 mM in water and to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Wiman (2010) Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. Oncogene. 29 4245. PMID: 20498645.

Boeckler et al (2008) Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc.Natl.Acad.Sci. 105 10360. PMID: 18650397.

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Keywords: PhiKan 083, supplier, PhiKan083, supplier, p53, stabilizing, stabilising, stabiliser, agent, transcription, factors, Y220C, mutation, thermostability, Tocris Bioscience, p53 products

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