Cat. No. 4326
Chemical Name: 9-Ethyl-N-methyl-9H-carbazole-3-met
Biological Activityp53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Wiman (2010) Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. Oncogene. 29 4245. PMID: 20498645.
Boeckler et al (2008) Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc.Natl.Acad.Sci. 105 10360. PMID: 18650397.
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Keywords: PhiKan 083, supplier, PhiKan083, supplier, p53, stabilizing, stabilising, stabiliser, agent, transcription, factors, Y220C, mutation, thermostability, Tocris Bioscience, p53 products
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April 22 - 26, 2017
Chicago, IL, USA