Cat. No. 4324

KC7F2 C16H16Cl4N2O4S4 [927822-86-4]

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Chemical Name: N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide

Biological Activity

Inhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Koh et al (2009) Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin.Cancer Res. 15 5945. PMID: 19789327.

Narita et al (2009) Identification of a novel small molecule HIF-1α translation inhibitor. Clin.Cancer Res. 15 6128. PMID: 19789328.

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Citations are publications that use Tocris products.

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Keywords: KC7F2, supplier, KC7F2, HIF-1a, HIF-1alpha, HIF-1α, inhibitors, inhibits, hypoxia-inducible, factors, downregulators, down-regulators, downregulation, down-regulation, Tocris Bioscience, Hypoxia Inducible Factor Inhibitor products

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