Cat. No. 4324
Chemical Name: N,N'-(Dithiodi-2,1-ethanediyl)bis[2,
Biological ActivityInhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Koh et al (2009) Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin.Cancer Res. 15 5945. PMID: 19789327.
Narita et al (2009) Identification of a novel small molecule HIF-1α translation inhibitor. Clin.Cancer Res. 15 6128. PMID: 19789328.
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