VU 0360172 hydrochloride
Cat. No. 4323
Chemical Name: N-Cyclobutyl-6-[2-(3-fluorophenyl)e
Biological ActivityPositive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). Selective for mGlu5; displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors. Exhibits antipsychotic-like activity in a rodent model. Also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
D'Amore et al (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology 66 330. PMID: 22705340.
Rodriguez et al (2010) Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol.Pharmacol. 78 (6) 1105. PMID: 20923853.
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