Cat. No. 4322
Chemical Name: N-[(3Z)-3-[(2-Ethyl-4-methyl-1H-imi
Biological ActivityIrreversible Nek2 inhibitor (IC50=770 nM). Inhibits Nek2 via alkylation of residue Cys22. Displays 5-fold selectivity for Nek2 over Cdk1. Exhibits no significant effect on Aurora B or Plk1 kinases, bipolar spindle assembly or spindle assembly checkpoint. Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Henise et al (2011) Irreversible Nek2 kinase inhibitors with cellular activity. J.Med.Chem. 54 4133. PMID: 21627121.
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Keywords: JH 295, supplier, JH295, Nek2, inhibitor, inhibits, irreversible, alkylation, Tocris Bioscience, Other Kinase Inhibitor products
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