FC 131

Cat. No. 4320

FC 131 Cyclo[2-Nal-Gly-D-Tyr-Arg-Arg]

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Biological Activity

CXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains).

Technical Data

M.Wt:
729.84
Formula:
C36H47N11O6
Sequence:
XGYRR (Modifications: Cyclic peptide, X = 2-Nal, Tyr-3 = D-Tyr]
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
606968-52-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Inokuchi et al (2011) Potent CXCR4 antagonists containing amidine type peptide bond isosteres. ACS Med.Chem.Lett. 2 477.

Tamamura et al (2005) Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131 J.Med.Chem. 48 380. PMID: 15658852.

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Keywords: FC 131, supplier, FC131, cxcr4, antagonists, chemokines, receptors, anti-HIV, Tocris Bioscience, Chemokine CXC Receptor Antagonist products

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