Cat. No. 4320
Biological ActivityCXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Inokuchi et al (2011) Potent CXCR4 antagonists containing amidine type peptide bond isosteres. ACS Med.Chem.Lett. 2 477.
Tamamura et al (2005) Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131 J.Med.Chem. 48 380. PMID: 15658852.
If you know of a relevant reference for FC 131 please let us know.
Citations are publications that use Tocris products.
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Keywords: FC 131, supplier, FC131, cxcr4, antagonists, chemokines, receptors, anti-HIV, Tocris Bioscience, Chemokine CXC Receptor Antagonist products
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