BX 795

Cat. No. 4318

BX 795 C23H26IN7O2S [702675-74-9]

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Chemical Name: N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

Biological Activity

Inhibitor of 3-phosphoinositide-dependent kinase 1 (PDPK1). Inhibits Akt phosphorylation at Thr308 in PC3 cells; also inhibits anchorage-independent growth of PC3 and MDA-MB-468 cells. Exhibits activity at other kinases, including TANK-binding kinase 1 (TBK1), Aurora B and IκB kinase ε (IKKε).

Technical Data

M.Wt:
591.47
Formula:
C23H26IN7O2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
702675-74-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Clark et al (2009) Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IκB kinase ε: a distinct upstream kinase mediates Ser-172 phosphorylation and activation. J.Biol.Chem. 284 14136. PMID: 19307177.

Tamguney et al (2008) Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells. Exp.Cell Res. 314 2299. PMID: 18514190.

Feldman et al (2005) Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J.Biol.Chem. 280 19867. PMID: 15772071.

If you know of a relevant reference for BX 795 please let us know.

Citations are publications that use Tocris products. Selected citations for BX 795 include:

Pillai et al (2015) Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis. Nat Commun 6 10072. PMID: 26656453.

Do you know of a great paper that uses BX 795 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: BX 795, supplier, BX795, pdk1, inhibitors, inhibits, 3-phosphoinositide-dependent, kinase-1, TBK1, TANK-binding, kinase, 1, Aurora, B, IkBe, IkappaBepsilon, IκBε, kinase, multi-kinase, PDPK1, Tocris Bioscience, Phosphoinositide-dependent Kinase 1 Inhibitor products

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