Cat. No. 4314
Chemical Name: N-Methyl-N-(2-methylphenyl)-3-nitro
Biological ActivitySelective non-peptide CGRP1 antagonist. Inhibits [125I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC50 values are 0.24 and 0.83 nM respectively).
Licensing InformationSold with the permission of GlaxoSmithKline.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Aiyar et al (2001) Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist. J.Pharmacol.Exp.Ther. 296 768. PMID: 11181905.
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Citations are publications that use Tocris products.
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Keywords: SB 268262, supplier, SB268262, CGRP, receptor, antagonist, calcitonin, gene-related, peptide, 1, antagonists, CGRP1, Tocris Bioscience, Calcitonin and Related Receptor Antagonist products
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