SB 268262

Cat. No. 4314

SB 268262 C18H15N3O4S2 [217438-17-0]

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Chemical Name: N-Methyl-N-(2-methylphenyl)-3-nitro-4-(2-thiazolylsulfinyl)-benzamide

Biological Activity

Selective non-peptide CGRP1 antagonist. Inhibits [125I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC50 values are 0.24 and 0.83 nM respectively).

Licensing Information

Sold with the permission of GlaxoSmithKline.

Technical Data

M.Wt:
401.46
Formula:
C18H15N3O4S2
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
217438-17-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Aiyar et al (2001) Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist. J.Pharmacol.Exp.Ther. 296 768. PMID: 11181905.

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Keywords: SB 268262, supplier, SB268262, CGRP, receptor, antagonist, calcitonin, gene-related, peptide, 1, antagonists, CGRP1, Tocris Bioscience, Calcitonin and Related Receptor Antagonist products

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