Nigericin sodium salt
Cat. No. 4312
Chemical Name: (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R
Biological ActivityPotassium ionophore, exchanges K+ for H+ across biological membranes, in a similar manner to Valinomycin (Cat. No. 3373). Stimulates mitochondral ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hamidinia et al (2004) The ionophore Nigericin transports Pb2+ with high activity and selectivity: A comparison to Monensin and Ionomycin. Biochemistry. 43 15956. PMID: 15595852.
Eytan et al (1990) Energy-linked transhydrogenase: Effects of Valinomycin and Nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted transhydrogenase-ATPase vesicles. J.Biol.Chem. 22 12949.
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Citations are publications that use Tocris products. Selected citations for Nigericin sodium salt include:
Lee et al (2016) Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome Cellular Immunology 306-307 53. PMID: 27423466.
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Keywords: Nigericin sodium salt, supplier, K+, potassium, ionophore, ionophores, exchanges, potassium, hydrogen, ions, exchanger, Tocris Bioscience, Ionophore products