Cat. No. 4311
Chemical Name: 4-[[[[(2-Methoxyphenyl)amino]carbon
Biological ActivityActivator of small-conductance Ca2+-activated K+ channels (KCa2); selective for KCa2.1 (EC50 = 8.2 μM in HEK293 cells expressing hKCa2.1) with the profile hKCa2.1 > hKCa2.2 = hKCa2.3 > hKCa3.1 (IK).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Hougaard et al (2009) Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methyoxy-phenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 298 in the S5 segment. Mol.Pharmacol. 76 569. PMID: 19515965.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses GW 542573X from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: GW 542573X, supplier, GW542573X, potassium, channels, activators, KCa2, KCa2.1, KCa2.2, KCa2.3, SK, channels, activators, SK1, activates, calcium-activated, potassium, channels, Tocris Bioscience, Calcium-Activated Potassium (KCa) Channel Activator products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.