ML 7 hydrochloride

Cat. No. 4310

ML 7 hydrochloride C15H17IN2O2S.HCl [110448-33-4]

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Chemical Name: Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride

Biological Activity

Selective MLCK inhibitor (Ki = 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.

Technical Data

M.Wt:
452.74
Formula:
C15H17IN2O2S.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
110448-33-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Meinders et al (2015) Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function. Blood 125 1957. PMID: 25538045.

Saitoh et al (1987) Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. J.Biol.Chem. 262 7796. PMID: 3108259.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ML 7 hydrochloride include:

Chaudhuri et al (2015) Substrate stress relaxation regulates cell spreading. J Neurosci 6 6364. PMID: 25695512.

Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest 125 1215. PMID: 25664854.

Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. Am J Physiol Renal Physiol 33 11206. PMID: 23825423.

Do you know of a great paper that uses ML 7 hydrochloride from Tocris? If so please let us know.

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Keywords: ML 7 hydrochloride, supplier, ML7, HCl, MLC, kinase, inhibitor, inhibits, myosin, light, chain, kinase, inhibitors, MLCKs, platelets, Tocris Bioscience, Myosin Light Chain Kinase Inhibitor products

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