ML 7 hydrochloride
Cat. No. 4310
Chemical Name: Hexahydro-1-[(5-iodo-1-naphthalenyl
Biological ActivitySelective MLCK inhibitor (Ki = 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Meinders et al (2015) Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function. Blood 125 1957. PMID: 25538045.
Saitoh et al (1987) Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. J.Biol.Chem. 262 7796. PMID: 3108259.
If you know of a relevant reference for ML 7 hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for ML 7 hydrochloride include:
Chaudhuri et al (2015) Substrate stress relaxation regulates cell spreading. J Neurosci 6 6364. PMID: 25695512.
Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest 125 1215. PMID: 25664854.
Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. Am J Physiol Renal Physiol 33 11206. PMID: 23825423.
Do you know of a great paper that uses ML 7 hydrochloride from Tocris? If so please let us know.
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Keywords: ML 7 hydrochloride, supplier, ML7, HCl, MLC, kinase, inhibitor, inhibits, myosin, light, chain, kinase, inhibitors, MLCKs, platelets, Tocris Bioscience, Myosin Light Chain Kinase Inhibitor products
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