Cat. No. 4309
Chemical Name: N,N,N',N'-Tetrakis(2-pyridylmethyl)et
Biological ActivityHeavy metal chelator. Reacts with both Zn-proteome and Zn-metallothionein (MT) in LLC-PK1 cells; acts as an intracellular chelator of proteomic Zn2+. Activity decreases intracellular zinc levels, and induces apoptosis in HeLa and cultured human retinal pigment epithelium (RPE) cells. Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Matias et al (2010) Validation of TPEN as a zinc chelator in fluorescence probing of calcium in cells with the indicator Fura-2. J.Fluoresc. 20 377. PMID: 19821015.
Rana et al (2008) Zinc binding ligands and cellular zinc trafficking: apo-metallothionein, glutathione, TPEN, proteomic zinc, and Zn-Sp1. J.Inorg.Biochem. 102 489. PMID: 18171589.
Chimienti et al (2001) Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors. Biochem.Pharmacol. 62 51. PMID: 11377396.
Hyun et al (2001) Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells. Invest.Opthalmol.Vis.Sci. 42 460.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TPEN from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: TPEN, supplier, zinc, zn2+, chelating, chelators, cell, permeable, permeant, heavy, metals, Tocris Bioscience, Biochemicals and Molecular Biology products
Find multiple products by catalog number
New Products in this Area
Photocrosslinker for hydrogelsGA3-AM
Gibberellin-analog (GA3) chemical dimerizer; cell permeableBicine
General purpose bufferACES
Buffer widely used in Western blottingCORM 2
Carbon monoxide-releasing molecule(S)-Norketamine hydrochloride
NMDA receptor modulator; analgesic2S,6S-Hydroxynorketamine hydrochloride
Decreases D-serine (a NMDA co-agonist); antidepressant2R,6R-Hydroxynorketamine hydrochloride
Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects(R)-Norketamine hydrochloride
NMDA receptor modulator; analgesicHaXS8
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.