Cat. No. 4305
Chemical Name: N-(2-Chloro-5-pyrimidinyl)-3,4-difl
Biological ActivitySelective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Provence et al (2015) The novel Kv7.2/Kv7.3 channel opener ICA-069673 reveals subtype-specific functional roles in guinea pig detrusor smooth muscle excitability and contractility. J.Pharmacol.Exp.Ther. 354 290. PMID: 26087697.
Amato et al (2011) N-pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy. ACS Med.Chem.Lett. 2 481. PMID: 24900334 .
If you know of a relevant reference for ICA 069673 please let us know.
Citations are publications that use Tocris products. Selected citations for ICA 069673 include:
Brueggemann et al (2014) Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol.Pharmacol. 2014 330. PMID: 24944189.
Do you know of a great paper that uses ICA 069673 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: ICA 069673, supplier, ICA069673, KCNQ2, KCNQ3, kv7.2, kv7.3, channel, opener, potassium, K+, voltage, gated, potassium, channel, openers, Kv, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Activator products
Find multiple products by catalog number
New Products in this Area
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.