Cat. No. 4303
Chemical Name: 6,7-Dihydro-7,9-dimethyl-6-(5-methy
Biological ActivityPotent, voltage-independent CFTR chloride channel inhibitor (IC50 = 90 nM). Reduces the size and number of renal cysts in an embryonic kidney culture model of polycystic kidney disease. Also increases VEGF-A production from airway epithelial cells in vitro.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Martin et al (2013) CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium. Eur.Resp.J. 42 1553. PMID: 23520314.
Tradtrantip et al (2009) Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J.Med.Chem. 52 6447. PMID: 19785436.
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Keywords: PPQ 102, supplier, PPQ102, potent, voltage, independent, CFTR, chloride, channel, inhibitors, inhibits, cystic, fibrosis, transmembrane, conductance, Tocris Bioscience, CFTR Blocker products