PPQ 102

Cat. No. 4303

PPQ 102 C26H22N4O3 [931706-15-9]

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Chemical Name: 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione

Biological Activity

Potent, voltage-independent CFTR chloride channel inhibitor (IC50 = 90 nM). Reduces the size and number of renal cysts in an embryonic kidney culture model of polycystic kidney disease. Also increases VEGF-A production from airway epithelial cells in vitro.

Technical Data

Soluble to 20 mM in DMSO with gentle warming
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Martin et al (2013) CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium. Eur.Resp.J. 42 1553. PMID: 23520314.

Tradtrantip et al (2009) Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J.Med.Chem. 52 6447. PMID: 19785436.

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Keywords: PPQ 102, supplier, PPQ102, potent, voltage, independent, CFTR, chloride, channel, inhibitors, inhibits, cystic, fibrosis, transmembrane, conductance, Tocris Bioscience, Chloride Channel Blocker products

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