TC 14012

Cat. No. 4300

TC 14012 Arg-Arg-Nal-Cys-Tyr-Cit-Lys-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2 (Modifications: Disulfide bridge between 4 - 13, Cit-8 = D-Citrulline)

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Biological Activity

CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).

Technical Data

M.Wt:
2066.43
Formula:
C90H140N34O19S2
Sequence:
RRACYXKXPYRXCR

(Modifications: Disulfide bridge between 4 - 13, Arg-14 = C-terminal amide, Ala-3 = 3-(2-naphthalenyllalanine), X-6 and X-12 = L-Citrulline, X-8 = D-Citrulline)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
368874-34-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Gravel et al (2010) The peptidomimetic CXCR4 antagonist TC14012 recruits beta arrestin to CXCR7: roles of receptor domains. J.Biol.Chem. 285 37939. PMID: 20956518.

Burger et al (2005) Small peptide inhibitors of the CXCR4 chemokine receptor (CS184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 106 1824. PMID: 15905192.

Tamamura et al (2003) Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org.Biomol.Chem. 1 3656. PMID: 14649896.

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Keywords: TC 14012, supplier, TC14012, cxcr4, antagonists, inverse, agonists, cxcr7, chemokines, Tocris Bioscience, Chemokine CXC Receptor Antagonist products

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