Cat. No. 4300
Biological ActivityCXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).
(Modifications: Disulfide bridge between 4 - 13, Arg-14 = C-terminal amide, Ala-3 = 3-(2-naphthalenyllalanine), X-6 and X-12 = L-Citrulline, X-8 = D-Citrulline)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Gravel et al (2010) The peptidomimetic CXCR4 antagonist TC14012 recruits beta arrestin to CXCR7: roles of receptor domains. J.Biol.Chem. 285 37939. PMID: 20956518.
Burger et al (2005) Small peptide inhibitors of the CXCR4 chemokine receptor (CS184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 106 1824. PMID: 15905192.
Tamamura et al (2003) Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org.Biomol.Chem. 1 3656. PMID: 14649896.
If you know of a relevant reference for TC 14012 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TC 14012 from Tocris? If so please let us know.
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Keywords: TC 14012, supplier, TC14012, cxcr4, antagonists, inverse, agonists, cxcr7, chemokines, Tocris Bioscience, Chemokine CXC Receptor Antagonist products
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