Pamoic acid disodium salt

Cat. No. 4298

Pamoic acid disodium salt C23H14Na2O6 [6640-22-8]

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Chemical Name: 4,4'-Methylenebis(3-hydroxy-2-naphthalenecarboxylic acid) disodium salt

Biological Activity

GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC50 values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.

Technical Data

Soluble to 100 mM in water and to 75 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683. PMID: 22967846.

Zhao et al (2010) Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol.Pharmacol. 78 560. PMID: 20826425.

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Keywords: Pamoic acid disodium salt, supplier, gpr35, orphan, gpcr, agonists, Tocris Bioscience, GPR35 Agonist products

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