SMER 28

Cat. No. 4297

SMER 28 C11H10BrN3 [307538-42-7]

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Chemical Name: 6-Bromo-N-2-propenyl-4-quinazolinamine

Biological Activity

Positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.

Technical Data

M.Wt:
264.12
Formula:
C11H10BrN3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
307538-42-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653. PMID: 27133794.

Renna et al (2010) Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J.Biol.Chem. 285 11061. PMID: 20147746.

Sarkar et al (2010) Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat.Chem.Biol. 3 331. PMID: 17486044.

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Citations are publications that use Tocris products. Selected citations for SMER 28 include:

Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653. PMID: 27133794.

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Keywords: SMER 28, supplier, SMER28, autophagy, inducer, induces, modulates, autophagy, MTOR-independent, small-molecule, enhancers, SMERs, Tocris Bioscience, Autophagy Activator products

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