VU 0357017 hydrochloride

Cat. No. 4295

VU 0357017 hydrochloride C18H27N3O3.HCl [1135242-13-5]

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Chemical Name: 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester hydrochloride

Biological Activity

Positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM). Displays no activity at M2-M5 at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.

Technical Data

M.Wt:
369.89
Formula:
C18H27N3O3.HCl
Solubility:
Soluble to 25 mM in water and to 5 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1135242-13-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Bridges et al (2010) Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M1 PAM. Bioorg.Med.Chem.Lett. 20 1972. PMID: 20156687.

Lebois et al (2010) Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system. ACS Chem.Neurosci. 1 104.

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Keywords: VU 0357017 hydrochloride, supplier, VU0357017, hydrochloride, muscarinics, acetylcholine, machrs, positive, allosteric, modulators, pams, m1, selective, Tocris Bioscience, M1 Receptor Modulator products

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