Cat. No. 4293
Chemical Name: 1-(2,4-Difluorophenyl)-5-[[2-[[(1,1
Biological ActivityCompetitive, reversible antagonist of the orphan receptor GPR35 (Ki = 12.8 nM). Blocks the GPR35-mediated increase in ERK1/2 phosphorylation and β-arrestin recruitment induced by pamoic acid (Cat. No. 4298).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683. PMID: 22967846.
Zhao et al (2010) Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol.Pharmacol. 78 560. PMID: 20826425.
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Keywords: CID 2745687, supplier, CID2745687, orphan, receptors, antagonists, GPR35, antagonist, Tocris Bioscience, GPR35 Antagonist products
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