CID 2745687

Cat. No. 4293

CID 2745687 C17H19F2N5O2S [264233-05-8]

Price and Availability

For CID 2745687 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1-(2,4-Difluorophenyl)-5-[[2-[[(1,1-dimethylehyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylic acid methyl ester

Biological Activity

Competitive, reversible antagonist of the orphan receptor GPR35 (Ki = 12.8 nM). Blocks the GPR35-mediated increase in ERK1/2 phosphorylation and β-arrestin recruitment induced by pamoic acid (Cat. No. 4298).

Technical Data

M.Wt:
395.43
Formula:
C17H19F2N5O2S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
264233-05-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683. PMID: 22967846.

Zhao et al (2010) Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol.Pharmacol. 78 560. PMID: 20826425.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses CID 2745687 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: CID 2745687, supplier, CID2745687, orphan, receptors, antagonists, GPR35, antagonist, Tocris Bioscience, GPR35 Antagonist products

Quick Order

Find multiple products by catalog number

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

New Products in this Area

ZQ 16

Selective GPR84 agonist

IHR-Cy3

Potent fluorescent Smo antagonist

Ro 6842262

Potent LPA1 antagonist

AMG 853

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist

AM 4668

Potent FFA1 (GPR40) agonist

CATPB

FFA2 antagonist/inverse agonist

Oleanolic acid

Selective GPBA receptor (TGR5) partial agonist

PPTN hydrochloride

High affinity and selective P2Y14 antagonist

Itraconazole

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.