SBE 13 hydrochloride

Cat. No. 4292

SBE 13 hydrochloride C24H27ClN2O4.HCl [1052532-15-6]

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Chemical Name: N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxybenzeneethanamine hydrochloride

Biological Activity

Selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). Exhibits no effect on Aurora kinase A activity. Binds and stabilizes the inactive form of PLK1. Delays cell cycle progression, reduces cell proliferation and induces apoptosis in a range of human cancer cell lines. Transiently arrests cells cycle at G0/G1 in primary cells.

Technical Data

M.Wt:
479.4
Formula:
C24H27ClN2O4.HCl
Solubility:
Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1052532-15-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Keppner et al (2011) Fate of primary cells at the G1/S boundary after Polo-like kinase 1 inhibition by SBE13. Cell Cycle 10 708. PMID: 21301227.

Eckerdt (2010) Freezing Polo in its sleep: targeting the inactive conformation of Polo-like kinase 1 in cancer cells. Cell Cycle 9 (5) 862. PMID: 20348843.

Keppner et al (2010) Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle 9 761. PMID: 20139717.

Liu (2010) SBE13 joins the family of Polo-like kinase 1 (Plk1) inhibitors. Cell Cycle 9 445. PMID: 20130451.

Keppner et al (2009) Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. ChemMedChem 4 1806. PMID: 19746360.

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Keywords: SBE 13 hydrochloride, supplier, SBE13, polo-like, kinases, plk1, plk, selective, potent, Tocris Bioscience, Polo-like Kinase Inhibitor products

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