RP 001 hydrochloride

Cat. No. 4289

RP 001 hydrochloride C24H24N4O4.HCl [1306761-53-4]

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Chemical Name: N-[4-[5-[3-Cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-iden-1-yl]-β-alanine hydrochloride

Biological Activity

Potent agonist of S1P1 receptors (EC50 = 9 pM). Induces internalization and polyubiquitination of S1P1 in vitro. Selective for S1P1 over S1P2 - S1P4.

Technical Data

M.Wt:
468.93
Formula:
C24H24N4O4.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1306761-53-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cahalan et al (2011) Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in mice. Nat.Chem.Biol. 7 254. PMID: 21445057.

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Keywords: RP 001 hydrochloride, supplier, RP001, sphingosine, 1, phosphate, s1p1, receptors, agonists, selective, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Agonist products

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