UA 62784

Cat. No. 4286

UA 62784 C23H15NO3 [313367-92-9]

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Chemical Name: 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-fluoren-9-one

Biological Activity

Inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine (Cat. No. 1256) in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity.

Technical Data

Soluble to 25 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Maiato and Logarinho et al (2011) Motor-dependent and -independent roles of CENP-E at kinetochores: the cautionary tale of UA62784. Chem.Biol. 18 679. PMID: 21700202.

Tcherniuk et al (2011) UA62784 is a cytotoxic inhibitor of microtubules, not CENP-E. Chem.Biol. 18 631. PMID: 21609844.

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Keywords: UA 62784, supplier, UA62784, cytotoxic, antiproliferatives, microtubules, inhibitors, inhibits, polymerization, polymerisation, Tocris Bioscience, Microtubule products

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