Cat. No. 4285
Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyra
Biological ActivityInhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.
Licensing InformationSold for research use only under patent license from Hybrigenics S.A.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Colombo et al (2010) Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem 5 552. PMID: 20186914.
Colland et al (2009) Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol.Cancer Ther. 8 2286. PMID: 19671755.
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Keywords: HBX 41108, supplier, HBX41108, ubiquitin-specific, proteases, usp7, selective, inhibitors, inhibits, proteasome, ubiquitin, deubiquitination, hausp, herpesvirus-associated, Tocris Bioscience, Deubiquitinating Enzyme Inhibitor products
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Novel USP7 inhibitor
Tocris is the exclusive supplier of HBX 41108 - a USP7 inhibitor licensed from Hybrigenics.