Cat. No. 4272
Biological ActivitySelective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy.
(Modifications: Trp-8 = D-Trp)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Patel et al (2010) Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J. 24 4835. PMID: 20702773.
Getting et al (2006) [D-Trp8]-γ-Melanocyte-stimulating-hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol.Pharmacol. 70 1850. PMID: 16959942.
Grieco et al (2000) D-amino acid scan of γ-melanocyte-stimulating hormone: importance of Trp8 on human MC3 receptor selectivity. J.Med.Chem. 43 4998. PMID: 11150170.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses [D-Trp8]-γ-MSH from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: [D-Trp8]-gamma-MSH, supplier, melanocortin, 3, receptors, MC3R, agonists, MC3, MC5, MC4, [D-Trp8]-gamma-MSH, [D-Trp8]-g-MSH, [D-Trp8]-γ-MSH, Tocris Bioscience, Melanocortin (MC) Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonistNeuropeptide S (Mouse)
Potent endogenous neuropeptide S receptor (NPSR) agonistML 382
MrgX1 (SNSR4) positive allosteric modulatorK-(D-1-Nal)-FwLL-NH2
High affinity and potent ghrelin receptor inverse agonistNeuropeptide S (Rat)
Potent endogenous neuropeptide S receptor agonistNeuropeptide S (human)
Potent endogenous neuropeptide S receptor agonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.