Cat. No. 4272
Biological ActivitySelective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy.
(Modifications: Trp-8 = D-Trp)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Patel et al (2010) Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J. 24 4835. PMID: 20702773.
Getting et al (2006) [D-Trp8]-γ-Melanocyte-stimulating-hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol.Pharmacol. 70 1850. PMID: 16959942.
Grieco et al (2000) D-amino acid scan of γ-melanocyte-stimulating hormone: importance of Trp8 on human MC3 receptor selectivity. J.Med.Chem. 43 4998. PMID: 11150170.
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Keywords: [D-Trp8]-gamma-MSH, supplier, melanocortin, 3, receptors, MC3R, agonists, MC3, MC5, MC4, [D-Trp8]-gamma-MSH, [D-Trp8]-g-MSH, [D-Trp8]-γ-MSH, Tocris Bioscience, Melanocortin (MC) Receptor Agonist products
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