Cat. No. 4270
Chemical Name: N1-(2-Aminophenyl)-N7-(4-methylphen
Biological ActivityClass I histone deacetylase (HDAC) inhibitor (IC50 values are 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively). Exhibits slow, tight-binding inhibitory activity. Displays no activity against class II HDACs. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Xu et al (2009) Chemical probes identify a role for histone deacetylase 3 in Friedrich's ataxia gene silencing. Chem.Biol. 16 980. PMID: 19778726.
Chou et al (2008) Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J.Biol.Chem. 283 35402. PMID: 18953021.
Rai et al (2008) HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. PLoS ONE 3 e1958. PMID: 18463734.
If you know of a relevant reference for TC-H 106 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TC-H 106 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: TC-H 106, supplier, TC-H106, histones, deacetylases, hdacs, inhibitiors, class, I, HDAC3, HDAC1, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Dual histone deacetylase (HDAC) 6/8 inhibitorTubastatin A hydrochloride
Potent HDAC6 inhibitorMS 275
HDAC (Class I) inhibitor
November 8 - 10, 2017