TC-H 106

Cat. No. 4270

TC-H 106 C20H25N3O2 [937039-45-7]

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Chemical Name: N1-(2-Aminophenyl)-N7-(4-methylphenyl)heptanediamide

Biological Activity

Class I histone deacetylase (HDAC) inhibitor (IC50 values are 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively). Exhibits slow, tight-binding inhibitory activity. Displays no activity against class II HDACs. Brain penetrant.

Technical Data

M.Wt:
339.43
Formula:
C20H25N3O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
937039-45-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Xu et al (2009) Chemical probes identify a role for histone deacetylase 3 in Friedrich's ataxia gene silencing. Chem.Biol. 16 980. PMID: 19778726.

Chou et al (2008) Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J.Biol.Chem. 283 35402. PMID: 18953021.

Rai et al (2008) HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. PLoS ONE 3 e1958. PMID: 18463734.

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Citations are publications that use Tocris products.

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Keywords: TC-H 106, supplier, TC-H106, histones, deacetylases, hdacs, inhibitiors, class, I, HDAC3, HDAC1, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products

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