Ro 1138452 hydrochloride

Cat. No. 4268

Ro 1138452 hydrochloride C19H23N3O.HCl

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Chemical Name: 4,5-Dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1H-imidazol-2-amine hydrochloride

Biological Activity

Selective prostacyclin IP receptor antagonist (pKi = 8.3). Exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailable.

Technical Data

M.Wt:
345.87
Formula:
C19H23N3O.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bley et al (2006) RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br.J.Pharmacol. 147 335. PMID: 16331286.

Jones et al (2006) Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations. Br.J.Pharmacol. 149 110. PMID: 16880763.

Clark et al (2004) Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg.Med.Chem.Lett. 14 1053. PMID: 15013022.

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Citations are publications that use Tocris products.

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Keywords: Ro 1138452 hydrochloride, supplier, Ro1138452, hydrochloride, supplier, IP, receptors, antagonists, prostanoid, prostaglandins, prostacyclins, eicosanoids, analgesic, CAS, 221529-58-4, Tocris Bioscience, Prostanoid Receptor Antagonist products

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