Cat. No. 4259
Chemical Name: (E)-4-(2-Phenylethenyl)-2-pyrimidin
Biological ActivityPositive allosteric modulator of mGlu4 receptors (EC50 = 1.0 μM for human and rat mGlu4 receptors). Orally available and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
East et al (2010) An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg.Med.Chem.Lett. 20 4901. PMID: 20638279.
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Citations are publications that use Tocris products. Selected citations for TCN 238 include:
Pershina and Arkhipov (2016) Subacute activation of mGlu4 receptors causes the feedback inhibition of its gene expression in rat brain. Life Sci. 153 50. PMID: 27055390.
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Keywords: TCN 238, supplier, TCN238, metabotropic, glutamate, mglu4, positive, allosteric, modulators, pams, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Modulator products