TAK 715

Cat. No. 4254

TAK 715 C24H21N3OS [303162-79-0]

Price and Availability

For TAK 715 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide

Biological Activity

Inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα). Also inhibits Wnt-3a-stimulated β-catenin signaling. Inhibits 22 kinases by more than 80%, including CK1δ/ε. Anti-inflammatory and anti-rheumatoid arthritis agent. Orally bioavailable.

Technical Data

M.Wt:
399.51
Formula:
C24H21N3OS
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
303162-79-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Verkaar et al (2011) Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε. Chem.Biol. 18 485. PMID: 21513885.

Miwatashi et al (2005) Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-{2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent. J.Med.Chem. 48 5966. PMID: 16162000.

If you know of a relevant reference for TAK 715 please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses TAK 715 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: TAK 715, supplier, TAK715, p38, MAPK, inhibitors, Mitogen-activated, protein, kinase, anti-inflammatory, inhibits, wnt, b-catenin, inhibitor, beta-catenin, casein, kinase, Tocris Bioscience, p38 MAPK Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

MAPK Signaling Review

Written by Aroon S. Karra and Melanie H. Cobb

MAPK Signaling  Scientific Review

Our MAPK signaling review gives an overview of the MAPK signaling cascade and summarizes small molecule inhibitors of the pathway. Request copy or view PDF today.

divider line

MAPK Signaling Pathway

MAPK Signaling Pathway

The MAPK family kinases respond to extracellular stimuli such as heat and stress to mediate intracellular signals. View pathway or download PDF today.

divider line

New Products in this Area

CC 401 dihydrochloride

High affinity JNK inhibitor; also inhibits HCMV replication

Org 48762-0

Selective p38α/β inhibitor; orally bioavailable

Sign-up for new product e-alerts
divider line

Neuroscience 2017

Win a $1,000 travel grant

Neuroscience 2017 Travel grant

Bio-Techne is offering 10 travel grants of $1,000 for Neuroscience 2017.