A 887826

Cat. No. 4249

A 887826 C26H29ClN4O3 [1266212-81-0]

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Chemical Name: 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide

Biological Activity

Potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV1.8 channels compared to NaV1.2 and NaV1.7 channels respectively.

Technical Data

M.Wt:
480.99
Formula:
C26H29ClN4O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>97 %
Storage:
Store at RT
CAS No:
1266212-81-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Zhang et al (2010) A-887826 is a structurally novel, potent and voltage-dependent NaV1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. Neuropharmacology 59 201. PMID: 20566409.

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Keywords: A 887826, supplier, A887826, sodium, channel, blocker, blocks, NaV1.8, voltage-dependent, ion, channels, antiallodynic, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products

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