Cat. No. 4249
Chemical Name: 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(
Biological ActivityPotent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV1.8 channels compared to NaV1.2 and NaV1.7 channels respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Zhang et al (2010) A-887826 is a structurally novel, potent and voltage-dependent NaV1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. Neuropharmacology 59 201. PMID: 20566409.
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Citations are publications that use Tocris products. Selected citations for A 887826 include:
Cho et al (2013) Injury-induced HDAC5 nuclear export is essential for axon regeneration. Nat Chem Biol 155 894. PMID: 24209626.
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Keywords: A 887826, supplier, A887826, sodium, channel, blocker, blocks, NaV1.8, voltage-dependent, ion, channels, antiallodynic, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products