Cat. No. 4249
Chemical Name: 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(
Biological ActivityPotent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV1.8 channels compared to NaV1.2 and NaV1.7 channels respectively.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Zhang et al (2010) A-887826 is a structurally novel, potent and voltage-dependent NaV1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. Neuropharmacology 59 201. PMID: 20566409.
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Keywords: A 887826, supplier, A887826, sodium, channel, blocker, blocks, NaV1.8, voltage-dependent, ion, channels, antiallodynic, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products
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