Torin 2

Cat. No. 4248

Torin 2 C24H15F3N4O [1223001-51-1]

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Chemical Name: 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one

Biological Activity

Potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Orally available.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Technical Data

M.Wt:
432.4
Formula:
C24H15F3N4O
Solubility:
Soluble to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1223001-51-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Simioni et al (2014) Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation. Oncotarget 30 10034. PMID: 25296981.

Liu et al (2011) Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J.Med.Chem. 54 1473. PMID: 21322566.

If you know of a relevant reference for Torin 2 please let us know.

Citations are publications that use Tocris products. Selected citations for Torin 2 include:

Hussain et al (2015) Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of Cisplatin in Epithelial Ovarian Cancer. Mol Med 21 466. PMID: 26023849.

Toops et al (2015) Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium. Nat Commun 26 41640. PMID: 25378587.

Yu et al (2015) PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation. BMC Biochem 6 7212. PMID: 25998442.

Ahmed et al (2014) High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma. Carcinogenesis 35 1564. PMID: 24583924.

Brown et al (2014) Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis. Mol Biol Cell 88 13149. PMID: 25187540.

Han et al (2014) Parallel measurement of dynamic changes in translation rates in single cells. Nat Methods 11 86. PMID: 24213167.

Zullo et al (2014) Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages. Cell 15 4. PMID: 24528777.

Hwang et al (2013) Protein phosphatase 2A isoforms utilizing Aβ scaffolds regulate differentiation through control of Akt protein. J Biol Chem 288 32064. PMID: 24052256.

Montané and Menand (2013) ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. J Virol 64 4361. PMID: 23963679.

Do you know of a great paper that uses Torin 2 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Torin 2, supplier, Torin2, mtor, mammalian, target, rapamycin, selective, inhibitors, inhibits, Tocris Bioscience, mTOR Inhibitor products

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