CID 2858522

Cat. No. 4246

CID 2858522 C28H39N3O3 [758679-97-9]

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Chemical Name: 1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]ethanone

Biological Activity

Selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production). Inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Does not inhibit other NF-κB pathways, including that activated by tumor necrosis factor (TNF).

Technical Data

M.Wt:
465.63
Formula:
C28H39N3O3
Solubility:
Soluble to 20 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
758679-97-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Peddibhotla et al (2010) Inhibition of protein kinase C-driven NF-κB activation: synthesis, SAR, and pharmacological profiling of pathway specific benzimidazole probe molecules. J.Med.Chem. 53 4793. PMID: 20481485.

Shi et al (2010) Chemical biology strategy reveals pathway-selective inhibitor of NF-κB activation induced by protein kinase C and antigen receptors. ACS Chem.Bio. 5 287.

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Keywords: CID 2858522, supplier, CID2858522, NF-kB, NF-kappaB, NF-κB, inhibitors, inhibits, PKC, protein, kinase, C-induced, activation, Tocris Bioscience, NF-κB and IκB Inhibitor products

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