Cat. No. 4246
Chemical Name: 1-[3,5-Bis(1,1-dimethylethyl)-4-hyd
Biological ActivitySelectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production). Inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Does not inhibit other NF-κB pathways, including that activated by tumor necrosis factor (TNF).
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Peddibhotla et al (2010) Inhibition of protein kinase C-driven NF-κB activation: synthesis, SAR, and pharmacological profiling of pathway specific benzimidazole probe molecules. J.Med.Chem. 53 4793. PMID: 20481485.
Shi et al (2010) Chemical biology strategy reveals pathway-selective inhibitor of NF-κB activation induced by protein kinase C and antigen receptors. ACS Chem.Bio. 5 287.
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Keywords: CID 2858522, supplier, CID2858522, NF-kB, NF-kappaB, NF-κB, inhibitors, inhibits, PKC, protein, kinase, C-induced, activation, Tocris Bioscience, NF-κB and IκB Inhibitor products
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