Cat. No. 4245
Alternative Name: Meclozine
Chemical Name: 1-[(4-Chlorophenyl)phenylmethyl]4-[
Biological ActivityHuman pregnane X receptor (hPXR) agonist; stronger activator of hPXR than rat PXR. Increases hPXR target gene expression in human hepatocyte primary cultures. Also acts as a histamine H1 receptor antagonist. Confers neuroprotection in models of polyQ toxicity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lau et al (2011) Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. J.Pharmacol.Exp.Ther. 336 816. PMID: 21131266.
Gohil et al (2010) Meclizine is neuroprotective in models of Huntington's disease. Hum.Mol.Genet. 20 294. PMID: 20977989.
Parada et al (2001) The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception. Neuroscience 102 937. PMID: 11182255.
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Keywords: Meclizine dihydrochloride, supplier, antihistamine, histaminergic, pregnane, x, receptors, pxr, hpxr, agonists, activators, neuroprotective, neuroprotectants, meclozine, Tocris Bioscience, Pregnane X Receptor Agonist products
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