Cat. No. 4242
Chemical Name: 6-(4-Chlorophenyl)-3-[3-methoxy-4-[
Biological ActivitySelective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). Displays antiobesity and antidepressant-like effects in rats and mice. Orally active.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Gehlert et al (2009) Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression. J.Pharmacol.Exp.Ther. 329 429. PMID: 19182070.
Rivera et al (2008) Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity. Curr.Med.Chem. 15 1025. PMID: 18393860.
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Keywords: GW 803430, supplier, glaxosmithkline, melanin, concentrating, hormone, receptors, mchr1, antagonists, antiobesity, obese, GW803430, Tocris Bioscience, Melanin-concentrating Hormone Receptor Antagonist products
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