SCH 529074

Cat. No. 4240

SCH 529074 C31H36Cl2N6 [922150-11-6]

Price and Availability

For SCH 529074 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine

Biological Activity

Restores mutant p53 activity. Binds p53 DNA binding domain (Kd = 1-2 μM) and restores wild-type function to many oncogenic mutants by acting as a chaperone. Inhibits ubiquitination of p53 by HDM2. Triggers apoptosis in tumor cell lines and reduces tumor growth in a xenograft model.

Technical Data

M.Wt:
563.56
Formula:
C31H36Cl2N6
Solubility:
Soluble to 100 mM in ethanol and to 10 mM in DMSO with sonication
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
922150-11-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Essmann & Schulze-Osthoff (2012) Translational approaches targeting the p53 pathway for anti-cancer therapy. Br.J.Pharmacol. 165 328. PMID: 21718309.

Demma et al (2010) SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53. J.Biol.Chem. 285 10198. PMID: 20124408.

If you know of a relevant reference for SCH 529074 please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses SCH 529074 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: SCH 529074, supplier, SCH529074, p53, activates, restores, mutant, p53, activity, induces, apoptosis, Transcription, Factors, HDM2, Tocris Bioscience, p53 products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Cell Cycle Life Science Poster

Cell Cycle & DNA Damage Repair Life Science Poster

Our Cell Cycle & DNA Damage Repair poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death. Request copy or view PDF today.

divider line

p53 Signaling Pathway

p53 Signaling Pathway

Signals through the p53 pathway are integral in the control of the cellular response different types of stress. View pathway or download PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.