SCH 529074

Cat. No. 4240

SCH 529074 C31H36Cl2N6 [922150-11-6]

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Chemical Name: N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine

Biological Activity

Restores mutant p53 activity. Binds p53 DNA binding domain (Kd = 1-2 μM) and restores wild-type function to many oncogenic mutants by acting as a chaperone. Inhibits ubiquitination of p53 by HDM2. Triggers apoptosis in tumor cell lines and reduces tumor growth in a xenograft model.

Technical Data

Soluble to 100 mM in ethanol and to 10 mM in DMSO with sonication
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Essmann & Schulze-Osthoff (2012) Translational approaches targeting the p53 pathway for anti-cancer therapy. Br.J.Pharmacol. 165 328. PMID: 21718309.

Demma et al (2010) SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53. J.Biol.Chem. 285 10198. PMID: 20124408.

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Keywords: SCH 529074, supplier, SCH529074, p53, activates, restores, mutant, p53, activity, induces, apoptosis, Transcription, Factors, HDM2, Tocris Bioscience, p53 products

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