Cat. No. 4234

4BP-TQS C18H17BrN2O2S [360791-49-7]

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Chemical Name: 4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide

Biological Activity

Allosteric agonist at α7 nAChR. Binds at a separate site and exhibits more efficacious receptor agonism compared to acetylcholine (Cat. No. 2809), displays 8-fold lower EC50 value and 45-fold larger maximal response.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Gill et al (2011) Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci.U.S.A. 108 5867. PMID: 21436053.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 4BP-TQS include:

Zhang et al (2015) Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor. Proc Natl Acad Sci U S A 10 e0137588. PMID: 26340537.

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Keywords: 4BP-TQS, supplier, alpha7, nAChR, a7, agonists, nicotinic, α7, Tocris Bioscience, Nicotinic (α7) Receptor Agonist products

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