Cat. No. 4233
Chemical Name: 3a,4,5,9b-Tetrahydro-4-(1-naphthale
Biological ActivityType II positive allosteric modulator of α7 nACh receptors (pEC50 = 5.5). Displays no agonist activity at α7 receptors at concentrations up to 0.1 mM; potentiates agonist-evoked responses and reduces rate of desensitization of α7 nAChRs. Exhibits potency and efficacy similar to PNU 120596 (Cat. No. 2498).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gill et al (2011) Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci. 108 5867.
Gronlien et al (2007) Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol.Pharmacol. 72 715. PMID: 17565004.
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Keywords: TQS, supplier, positive, allosteric, modulators, pam, alpha, α, a7, nicotinic, receptors, nachr, type, II, Tocris Bioscience, Nicotinic (α7) Receptor Modulator products