Cat. No. 4228
Chemical Name: (2E)-1-(4-Acetyl-1-piperazinyl)-3-[
Biological ActivityPotent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Liu et al (2000) Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J.Med.Chem. 43 4025. PMID: 11052808.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses A 286982 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: A 286982, supplier, A286982, LFA-1/ICAM-1, inhibitors, cellular, adhesion, leukocyte, function-associated, antigen-1, inhibits, Tocris Bioscience, Integrin Receptor Inhibitor products
Find multiple products by catalog number
New Products in this Area
α5β1 integrin receptor antagonistFSL 1
TLR2/6 agonist (also a putative TLR10 ligand)Cilengitide
Potent and selective inhibitor of integrins αvβ3 and αvβ5
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.