Cat. No. 4228
Chemical Name: (2E)-1-(4-Acetyl-1-piperazinyl)-3-[
Biological ActivityPotent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Liu et al (2000) Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J.Med.Chem. 43 4025. PMID: 11052808.
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Keywords: A 286982, supplier, A286982, LFA-1/ICAM-1, inhibitors, cellular, adhesion, leukocyte, function-associated, antigen-1, inhibits, Tocris Bioscience, Integrin Inhibitor products
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