RWJ 50271

Cat. No. 4227

RWJ 50271 C18H17F3N4O2S [162112-37-0]

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Chemical Name: N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide

Biological Activity

Selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells).

Technical Data

M.Wt:
410.41
Formula:
C18H17F3N4O2S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
162112-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Sanfilippo et al (1995) Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. J.Med.Chem. 38 1057. PMID: 7707308.

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Keywords: RWJ 50271, supplier, RWJ50271, inhibitors, inhibits, LFA-1/ICAM-1, adhesion, sICAM, lymphocyte, function-associated, antigen-1, Tocris Bioscience, Integrin products

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