Cat. No. 4221
Alternative Name: NIBR3049
Chemical Name: 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopr
Biological ActivityPotent JAK3 inhibitor (IC50 = 8 nM). Selective for JAK3 over JAK1, JAK2 and TYK2 (IC50 values are 1017, 2550 and 8055 nM respectively). Also inhibits GSK-3β, PKCα and PKCθ (IC50 values are 3, 13 and 68 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Thoma et al (2010) Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family. J.Med.Chem. 54 284.
If you know of a relevant reference for TCS 21311 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TCS 21311 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TCS 21311, supplier, TCS21311, janus, kinases, jaks, jak3, inhibitors, inhibits, selective, potent, Tocris Bioscience, JAK Kinase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Inhibitor of Clk and DYRK kinasesEverolimus
mTOR inhibitor;immunosuppressantPKI (5-24)
High affinity PKA inhibitorTDZD 8
Selective non-ATP competitive inhibitor of GSK 3βBI 605906
Selective IKKβ inhibitorGSK 319347A
Potent and selective IKKε inhibitorFRAX 597
Potent group I PAK inhibitorMRT 68921 dihydrochloride
Potent ULK inhibitor; inhibits autophagyAM 2394
Potent glucokinase activator; orally bioavailableeCF 309
Potent mTOR inhibitorPF 3758309 dihydrochloride
Potent PAK4 inhibitor; orally availableAZ Dyrk1B 33
Potent and selective Dyrk1B kinase inhibitorPF 06409577
Potent and selective allosteric activator of AMPKPerifosine
PKB/Akt inhibitor; also modulates Kv2.1 currentRAF 265
Raf kinase and VEGFR-2 inhibitorCZC 25146
Potent LRRK2 inhibitorRo 3280
Potent and selective PLK1 inhibitorRMM 46
MSK/RSK family kinase inhibitorLTURM 34
Potent DNA-PK inhibitorMLi-2
Potent and selective LRRK2 inhibitorLTURM 36
PI 3-kinase δ inhibitorPI 3065
Potent and selective PI 3-kinase p110δ inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.