TCS 21311

Cat. No. 4221

TCS 21311 C27H25F3N4O4 [1260181-14-3]

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Alternative Name: NIBR3049

Chemical Name: 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Biological Activity

Potent JAK3 inhibitor (IC50 = 8 nM). Selective for JAK3 over JAK1, JAK2 and TYK2 (IC50 values are 1017, 2550 and 8055 nM respectively). Also inhibits GSK-3β, PKCα and PKCθ (IC50 values are 3, 13 and 68 nM respectively).

Technical Data

M.Wt:
526.51
Formula:
C27H25F3N4O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1260181-14-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Thoma et al (2010) Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family. J.Med.Chem. 54 284.

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Citations are publications that use Tocris products.

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Keywords: TCS 21311, supplier, TCS21311, janus, kinases, jaks, jak3, inhibitors, inhibits, selective, potent, Tocris Bioscience, JAK Kinase Inhibitor products

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