Banoxantrone dihydrochloride

Cat. No. 4219

Banoxantrone dihydrochloride C22H28N4O6.2HCl [252979-56-9]

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Alternative Name: AQ4N

Chemical Name: 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride

Biological Activity

Bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100 μM). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.

Technical Data

M.Wt:
517.4
Formula:
C22H28N4O6.2HCl
Solubility:
Soluble to 50 mM in water and to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
252979-56-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Mehibel et al (2009) Effects of cytokine-induced macrophages on the response of tumor cells to banoxantrone (AQ4N). Mol.Cancer Ther. 8 1261. PMID: 19435866.

Friery et al (2000) Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine. Br.J.Cancer 82 1469. PMID: 10780528.

Patterson and McKeown (2000) AQ4N: a new approach to hypoxia-activated cancer chemotherapy. Br.J.Cancer 83 1589. PMID: 11104551.

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Keywords: Banoxantrone dihydrochloride, supplier, AQ4N, prodrug, hypoxia, hypoxic, cytotoxic, topoisomerase, II, inhibitors, inhibits, antitumor, antitumour, chemotherapeutics, Tocris Bioscience, DNA Topoisomerase Inhibitor products

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