Travaprost

Cat. No. 4218

Travaprost C26H35F3O6 [157283-68-6]

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Chemical Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid 1-methyethyl ester

Biological Activity

FP prostaglandin receptor agonist. Exhibits submicromolar affinity for DP, EP, IP and TP receptors. Stimulates intracellular Ca2+ mobilization. Ocular hypotensive agent.

Technical Data

M.Wt:
500.55
Formula:
C26H35F3O6
Solubility:
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 10mg/ml)
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
157283-68-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hellberg et al (2001) Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J.Ocul.Pharmacol.Ther. 17 421. PMID: 11765147.

Sharif et al (1999) [3H]AL-5848 ([3H]9beta-(+)-Fluprostenol). Carboxylic acid of travoprost (AL-6221), a novel FP prostaglandin to study the pharmacology and autoradiographic localization of the FP receptor. J.Pharm.Pharmacol. 51 685. PMID: 10454045.

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Citations are publications that use Tocris products.

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Keywords: Travaprost, supplier, Supplier, Travoprost, FP, receptor, agonist, prostaglandin, F2a, F2alpha, prostaglandin, ocular, hypotensive, Tocris Bioscience, Prostanoid Receptor Agonist products

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