Cat. No. 4215

4E1RCat C28H18N2O6 [328998-25-0]

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Chemical Name: 4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid

Biological Activity

Inhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50 ~4 μM). Exhibits chemosensitizing properties.

Technical Data

Soluble to 50 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Cencic et al (2010) Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc.Natl.Acad.Sci.USA 108 1046.

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Citations are publications that use Tocris products. Selected citations for 4E1RCat include:

Arnold et al (2014) Regulation of cardiac expression of the diabetic marker microRNA miR-29. PLoS One 9 e103284. PMID: 25062042.

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Keywords: 4E1RCat, supplier, eIF4F, inhibitors, inhibits, protein, synthesis, chemosensitizing, chemosensitizer, cap, dependent, translation, eIF4E, eIF4G, 4E-BP1, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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