Cat. No. 4215
Chemical Name: 4-[(3E)-3-[[5-(4-Nitrophenyl)furan-
Biological ActivityInhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50 ~4 μM). Exhibits chemosensitizing properties.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Cencic et al (2010) Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc.Natl.Acad.Sci.USA 108 1046.
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Citations are publications that use Tocris products. Selected citations for 4E1RCat include:
Arnold et al (2014) Regulation of cardiac expression of the diabetic marker microRNA miR-29. PLoS One 9 e103284. PMID: 25062042.
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Keywords: 4E1RCat, supplier, eIF4F, inhibitors, inhibits, protein, synthesis, chemosensitizing, chemosensitizer, cap, dependent, translation, eIF4E, eIF4G, 4E-BP1, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products
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