PIR 3.5

Cat. No. 4212

PIR 3.5 C20H14O2S2 [6088-51-3]

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Chemical Name: 6,6'-Dithiodi-2-naphthtol

Biological Activity

Negative control of IPA 3 (Cat. No. 3622) a direct, non-competitive inhibitor of group I p21-activated kinase (Pak1).

Technical Data

M.Wt:
350.45
Formula:
C20H14O2S2
Solubility:
Soluble to 75 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
6088-51-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Deacon et al (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem.Biol. 15 322. PMID: 18420139.

If you know of a relevant reference for PIR 3.5 please let us know.

Citations are publications that use Tocris products. Selected citations for PIR 3.5 include:

Imle et al (2015) Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. MBio 6. PMID: 26350970.

Molosh et al (2014) Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase. J Biol Chem 17 1583. PMID: 25242307.

Do you know of a great paper that uses PIR 3.5 from Tocris? If so please let us know.

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Keywords: PIR 3.5, supplier, PIR, 3.5, PIR3.5, negative, control, IPA-3, inhibits, Pak1, inhibitors, Tocris Bioscience, P21-activated Kinases products

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